Acute lower limb ischemia as the initial symptom of acute myeloid leukemia

Although coagulatory system disorders are well recognized in patients with acute leukemia, these usually present with either hemorrhagic complications or thrombosis of small vessels. Large vessel thrombosis is a very rare clinical presentation. We present a patient with previously undiagnosed acute...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2007-08, Vol.12 (3), p.199-202
Main Authors: Kafetzakis, Alexandros, Foundoulakis, Andreas, Ioannou, Christos V, Stavroulaki, Emilia, Koutsopoulos, Anastassios, Katsamouris, Asterios N
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Arterial Occlusive Diseases - etiology
Arterial Occlusive Diseases - physiopathology
Arterial Occlusive Diseases - surgery
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular system
Coronary heart disease
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Heart
Humans
Ischemia - etiology
Ischemia - physiopathology
Ischemia - therapy
Leg - blood supply
Leg - surgery
Leukapheresis
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - physiopathology
Leukemia, Myeloid, Acute - therapy
Male
Medical sciences
Pharmacology. Drug treatments
Pulmonary Disease, Chronic Obstructive - pathology
Smoking
Thrombectomy
Thrombosis - etiology
Vasodilator agents. Cerebral vasodilators
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Summary:Although coagulatory system disorders are well recognized in patients with acute leukemia, these usually present with either hemorrhagic complications or thrombosis of small vessels. Large vessel thrombosis is a very rare clinical presentation. We present a patient with previously undiagnosed acute myeloid leukemia (M5), who was referred to our hospital with symptoms of acute ischemia of his right lower limb. Occlusion of the right external iliac artery due to a combination of leucostasis and coagulation disorders was noted and successfully treated with urgent leukapheresis, immediate chemotherapy and surgical thromboembolectomy.
ISSN:1358-863X
1477-0377
DOI:10.1177/1358863X07080630