Cellular adhesion molecules and peripheral arterial disease

Cellular adhesion molecules (CAMs), by mediating the recruitment of circulating leukocytes to the blood vessel wall and their subsequent migration into the subendothelial spaces, play a crucial role in all stages of atherosclerosis. Soluble forms of CAMs, probably derived from proteolytic shedding,...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2006-02, Vol.11 (1), p.39-47
Main Authors: Brevetti, Gregorio, Schiano, Vittorio, Chiariello, Massimo
Format: Article
Language:English
Subjects:
Angioplasty, Balloon
Animals
Atherosclerosis - blood
Atherosclerosis - prevention & control
Atherosclerosis - therapy
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Cardiology. Vascular system
Cell Adhesion Molecules - blood
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
General and cellular metabolism. Vitamins
Humans
Immunoglobulins - blood
Integrins - blood
Intermittent Claudication - blood
Intermittent Claudication - prevention & control
Intermittent Claudication - therapy
Lower Extremity - blood supply
Medical sciences
Peripheral Vascular Diseases - blood
Peripheral Vascular Diseases - prevention & control
Peripheral Vascular Diseases - therapy
Pharmacology. Drug treatments
Recurrence
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Selectins - blood
Severity of Illness Index
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Summary:Cellular adhesion molecules (CAMs), by mediating the recruitment of circulating leukocytes to the blood vessel wall and their subsequent migration into the subendothelial spaces, play a crucial role in all stages of atherosclerosis. Soluble forms of CAMs, probably derived from proteolytic shedding, are present in the circulation and their blood levels parallel the amount expressed on the cell surface. In patients with peripheral arterial disease (PAD), increased levels of soluble CAMs have been found during exercise-induced claudication, are associated with the presence, the severity and the extent of atherosclerosis in the arteries of the lower limbs, and portend a worse outcome. These findings have provided new insights into the pathophysiology of PAD and its consequences. However, further large population studies are needed to firmly establish whether increased levels of circulating CAMs give additive information to current risk assessment approaches, and to verify whether PAD patients with elevated levels of circulating CAMs would benefit from any specific therapy.
ISSN:1358-836X
1358-863X
1477-0377
DOI:10.1191/1358863x06vm645ra