Ruthenium-Catalyzed Cascade N- and C(3)-Dialkylation of Cyclic Amines with Alcohols Involving Hydrogen Autotransfer Processes

An unprecented N‐ and C(3)‐dialkylation of unactivated amines by a cascade reaction via borrowing hydrogen methodology using new (arene)ruthenium(II) complexes featuring phosphinosulfonate ligands is described. This reaction is highly regioselective and produces water as the only side product.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2010-12, Vol.352 (18), p.3141-3146
Main Authors: Sundararaju, Basker, Tang, Zhou, Achard, Mathieu, Sharma, Gangavaram V. M., Toupet, Loïc, Bruneau, Christian
Format: Article
Language:English
Subjects:
Alcohols
Amines
borrowing hydrogen
Cascades
Catalysis
Chemical Sciences
homogeneous catalysis
hydrogen autotransfer
Ligands
Methodology
O chelates
P,O chelates
ruthenium
Synthesis
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Description
Summary:An unprecented N‐ and C(3)‐dialkylation of unactivated amines by a cascade reaction via borrowing hydrogen methodology using new (arene)ruthenium(II) complexes featuring phosphinosulfonate ligands is described. This reaction is highly regioselective and produces water as the only side product.
ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.201000546