Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are repo...

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Bibliographic Details
Published in:Tetrahedron 2009-12, Vol.65 (50), p.10424-10429
Main Authors: Festa, Carmen, De Marino, Simona, Sepe, Valentina, Monti, Maria Chiara, Luciano, Paolo, D'Auria, Maria Valeria, Débitus, Cecile, Bucci, Mariarosaria, Vellecco, Valentina, Zampella, Angela
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Chemistry
Exact sciences and technology
General pharmacology
Life Sciences
Marine
Medical sciences
Organic chemistry
Peptides
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Preparations and properties
Theonella swinhoei
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Summary:Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are reported. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2009.10.026