Iron overload in MDS--pathophysiology, diagnosis, and complications

Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among ir...

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Bibliographic Details
Published in:Annals of hematology 2011-01, Vol.90 (1), p.1-10
Main Authors: Gattermann, Norbert, Rachmilewitz, Eliezer A
Format: Article
Language:English
Subjects:
Animals
Blood Transfusion
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Hematology
Humans
Iron Chelating Agents - therapeutic use
Iron chelation
Iron overload
Iron Overload - complications
Iron Overload - diagnosis
Iron Overload - epidemiology
Iron Overload - etiology
Labile plasma iron
Life Expectancy
Medicine
Medicine & Public Health
Models, Biological
Myelodysplastic syndromes
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - epidemiology
Myelodysplastic Syndromes - therapy
Non-transferrin-bound iron
Oncology
oxidative stress
Oxidative Stress - physiology
Review Article
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Summary:Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Here, we discuss our current understanding of the effects of transfusion dependency and iron overload in MDS, indicate our knowledge gaps, and suggest that particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron, which may be as important as the total iron burden.
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-010-1091-1