Evaluation of azithromycin, trovafloxacin and grepafloxacin as prophylaxis for experimental murine melioidosis

Abstract The efficacies of the azalide azithromycin and the fluoroquinolones trovafloxacin and grepafloxacin for pre- and post-exposure prophylaxis of infection with high or low challenge doses of Burkholderia pseudomallei strain 576 were assessed in an experimental mouse model. Trovafloxacin and gr...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2010-07, Vol.36 (1), p.87-89
Main Authors: Kenny, Dermot J, Sefton, Armine M, Brooks, Timothy J.G, Laws, Thomas R, Simpson, Andrew J.H, Atkins, Helen S
Format: Article
Language:English
Subjects:
Animal models
Animals
Anti-Bacterial Agents - therapeutic use
Antibiotic Prophylaxis - methods
Antibiotics. Antiinfectious agents. Antiparasitic agents
Azithromycin - therapeutic use
Bacterial diseases
Biological and medical sciences
Burkholderia
Burkholderia pseudomallei
Burkholderia pseudomallei - drug effects
Burkholderia pseudomallei - isolation & purification
Disease Models, Animal
Female
Fluoroquinolone
Fluoroquinolones - therapeutic use
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Macrolide
Medical sciences
Melioidosis
Melioidosis - prevention & control
Mice
Mice, Inbred BALB C
Mouse
Naphthyridines - therapeutic use
Pharmacology. Drug treatments
Piperazines - therapeutic use
Survival Analysis
Tropical bacterial diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The efficacies of the azalide azithromycin and the fluoroquinolones trovafloxacin and grepafloxacin for pre- and post-exposure prophylaxis of infection with high or low challenge doses of Burkholderia pseudomallei strain 576 were assessed in an experimental mouse model. Trovafloxacin and grepafloxacin afforded significant levels of protection, whereas azithromycin was ineffective and potentially detrimental. Overall, the data suggest that some fluoroquinolones may have potential utility in prophylaxis of melioidosis and suggest that azithromycin would not be effective in prophylaxis of B. pseudomallei infection.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2010.03.019