A Markov chain description of the stepwise mutation model: Local and global behaviour of the allele process

The stepwise mutation model (SMM) is a simple, widely used model to describe the evolutionary behaviour of microsatellites. We apply a Markov chain description of the SMM and derive the marginal and joint properties of this process. In addition to the standard SMM, we also consider the normalised al...

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Bibliographic Details
Published in:Journal of theoretical biology 2010-09, Vol.266 (2), p.336-342
Main Authors: Caliebe, Amke, Jochens, Arne, Krawczak, Michael, Rösler, Uwe
Format: Article
Language:English
Subjects:
Alleles
Asymptotic behaviour
Computer Simulation
Evolution
Evolution, Molecular
Genetics, Population
Markov Chains
Microsatellite
Microsatellite Repeats - genetics
Models, Genetic
Mutation - genetics
Population genetics
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Summary:The stepwise mutation model (SMM) is a simple, widely used model to describe the evolutionary behaviour of microsatellites. We apply a Markov chain description of the SMM and derive the marginal and joint properties of this process. In addition to the standard SMM, we also consider the normalised allele process. In contrast to the standard process, the normalised process converges to a stationary distribution. We show that the marginal stationary distribution is unimodal. The standard and normalised processes capture the global and the local behaviour of the SMM, respectively.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2010.06.033