Revisited Synthesis of Aryl-H-phosphinates

Abstract A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petneházy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via d...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2011-08, Vol.2011 (15), p.2490-2494
Main Authors: Volle, Jean-Noël, Filippini, Damien, Midrier, Camille, Sobecki, Michal, Drag, Marcin, Virieux, David, Pirat, Jean-Luc
Format: Article
Language:English
Subjects:
Chemical Sciences
Chemistry
Exact sciences and technology
Organic chemistry
Organometalloidal and organometallic compounds
P derivatives
Preparations and properties
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Summary:Abstract A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petneházy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-H-phosphinates in high yields and purities.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0030-1260109