Modulation of the postprandial acid and bile pockets at the gastro‐oesophageal junction by drugs that affect gastric motility

Summary Background  Previous studies have established the presence of a postprandial acid pocket at the gastro‐oesophageal junction. Aims  To investigate whether altering gastric motility would affect the location and the extent of postprandial acid pockets in healthy volunteers and also to study th...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2011-06, Vol.33 (12), p.1370-1377
Main Authors: Boecxstaens, V., Bisschops, R., Blondeau, K., Vos, R., Scarpellini, E., De Wulf, D., Tack, J.
Format: Article
Language:English
Subjects:
Adult
Bile - drug effects
Bile - metabolism
Biological and medical sciences
Digestive system
Erythromycin - administration & dosage
Esophagogastric Junction - drug effects
Esophagogastric Junction - metabolism
Female
Gastric Acid - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydrogen-Ion Concentration
Male
Medical sciences
Pharmacology. Drug treatments
Placebos - administration & dosage
Postprandial Period
Sumatriptan - administration & dosage
Treatment Outcome
Young Adult
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Summary:Summary Background  Previous studies have established the presence of a postprandial acid pocket at the gastro‐oesophageal junction. Aims  To investigate whether altering gastric motility would affect the location and the extent of postprandial acid pockets in healthy volunteers and also to study the presence of bile in this pocket. Methods  A total of 16 healthy volunteers underwent pH and Bilitec probe stepwise pull‐through to measure regional differences in pH and bile absorbance before and 10, 30 and 50 min after a liquid meal. At the start of the meal, saline, erythromycin or sumatriptan was administered. Results  After saline, ingestion of a meal induced an acid pocket, with a mean pH drop of 2.26 (compared to 0.25 before the meal, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2011.04664.x