Virologic failure in an HIV-infected woman given desogestrel for excessive menstrual bleeding

Numerous studies have investigated the impact of hormonal treatment on HIV acquisition, transmission and/or disease progression [1, 2]. Experimental observations have provided evidence that progesterone-based therapies can increase viral replication either by directly altering HIV-1 transcriptional...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2011-04, Vol.67 (4), p.429-431
Main Authors: Cattaneo, Dario, Meraviglia, Paola, Beretta, Rosangela, Baldelli, Sara, Cozzi, Valeria, Milani, Greta, Clementi, Emilio
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
CD4 Lymphocyte Count - statistics & numerical data
Desogestrel - adverse effects
Drug therapy
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
Human immunodeficiency virus
Humans
Letter to the Editors
Menorrhagia - complications
Menorrhagia - drug therapy
Menstruation
Metrorrhagia - complications
Metrorrhagia - drug therapy
Pharmacology/Toxicology
Progestins - adverse effects
Viral Load - drug effects
Viral Load - statistics & numerical data
Virus Replication - drug effects
Womens health
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Summary:Numerous studies have investigated the impact of hormonal treatment on HIV acquisition, transmission and/or disease progression [1, 2]. Experimental observations have provided evidence that progesterone-based therapies can increase viral replication either by directly altering HIV-1 transcriptional activation and/or through regulation of cytokine and chemokine secretion [13]. Clinical studies have, however, provided conflicting results.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-010-0934-y