Effect of antiretrovirals on semen quality

The aim of this cross-sectional study was to determine which antiretroviral drugs (ARVs) are associated with changes in the characteristics of semen and the impact of these ARVs according to their score penetration into the male genital compartment. Data from 144 men infected with HIV-1 enrolled in...

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Bibliographic Details
Published in:Journal of medical virology 2011-06, Vol.83 (8)
Main Authors: Lambert-Niclot, Sidonie, Poirot, Catherine, Tubiana, Roland, Houssaini, Allal, Soulié, Cathia, Dominguez, Stephanie, Schubert, Benoit, Prades, Marie, Bonmarchand, Manuela, Calvez, Vincent, Flandre, Philippe, Peytavin, Gilles, Marcelin, Anne-Geneviève
Format: Article
Language:English
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Summary:The aim of this cross-sectional study was to determine which antiretroviral drugs (ARVs) are associated with changes in the characteristics of semen and the impact of these ARVs according to their score penetration into the male genital compartment. Data from 144 men infected with HIV-1 enrolled in an Assisted Reproductive Technology program were analyzed retrospectively. A seminal penetration score of ARV was based on the available literature. The nonparametric Kruskal-Wallis test and Khi-2 test were used. There was no difference on sperm parameters between NRTI, NNRTI or PI regimen. In patients receiving NRTIs or PIs no differences were observed between antiretrovirals of these classes. However in patients receiving NNRTIs, nevirapine (n=22) was associated with a higher percentage of progressively motile spermatozoa (p
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.22119