In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemica...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (6), p.910-912
Main Authors: Dubar, Faustine, Bohic, Sylvain, Slomianny, Christian, Morin, Jean-Charles, Thomas, Patrick, Kalamou, Hadidjatou, Guérardel, Yann, Cloetens, Peter, Khalife, Jamal, Biot, Christophe
Format: Article
Language:English
Subjects:
Aminoquinolines - chemistry
Aminoquinolines - metabolism
Aminoquinolines - pharmacology
Antimalarials - metabolism
Antimalarials - pharmacology
Biochemistry
Biochemistry, Molecular Biology
Biological Transport
Erythrocytes - metabolism
Ferrous Compounds - chemistry
Ferrous Compounds - metabolism
Ferrous Compounds - pharmacology
Life Sciences
Mass Spectrometry
Microscopy, Electron, Transmission
Plasmodium
Plasmodium falciparum - drug effects
Plasmodium falciparum - ultrastructure
Spectrometry, X-Ray Emission
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Summary:We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16211j