Biocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly(l-glutamic acid) Polymersomes: Size Control and Stability

Poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) diblock copolymers have been synthesized by ring-opening polymerization (ROP) of γ-benzyl-l-glutamate N-carboxyanhydride (BLG) initiated by amino functionalized PTMC and subsequent hydrogenation. Self-assembly in water gave well-defin...

Full description

Saved in:
Bibliographic Details
Published in:Langmuir 2010-02, Vol.26 (4), p.2751-2760
Main Authors: Sanson, Charles, Schatz, Christophe, Le Meins, Jean-François, Brûlet, Annie, Soum, Alain, Lecommandoux, Sébastien
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Chemical Sciences
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites
Membranes
Particle Size
Polyethylene Terephthalates - chemistry
Polyethylene Terephthalates - metabolism
Polyglutamic Acid - chemistry
Polyglutamic Acid - metabolism
Polymers
Surface physical chemistry
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) diblock copolymers have been synthesized by ring-opening polymerization (ROP) of γ-benzyl-l-glutamate N-carboxyanhydride (BLG) initiated by amino functionalized PTMC and subsequent hydrogenation. Self-assembly in water gave well-defined vesicles which have been studied combining light and neutron scattering techniques with electron microscopy imaging. The size and dispersity of vesicles have been tuned by varying preparation conditions, direct dissolution, or nanoprecipitation. In addition, PGA conformation could be reversibly manipulated as a function of environmental changes such as pH and ionic strength. Vesicles showed high tolerance and stability toward nonionic surfactant and pH due to a thick membrane and were revealed to be nonpermeable to water. Nevertheless, they can be rapidly degraded by enzymatic hydrolysis of the polycarbonate block. The ability to tune their size through the formation process, their stimuli responsiveness, their high stability, and their biodegradability make them suitable for biomedical applications.
ISSN:0743-7463
1520-5827
DOI:10.1021/la902786t