Strategies for patients with newly diagnosed oral squamous cell carcinoma and a positive chest CT. A cohort study on the effects on treatment planning and incidence

• Published in: European journal of surgical oncology 2011-03, Vol.37 (3), p.272-277
• Main Authors: Jaspers, G.W, Witjes, M.J, Groen, H.J, Groen, H, Rödiger, L.A, Roodenburg, J.L
• Format: Article
• Language: English
• Subjects: Aged; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Chest CT; Contrast Media; Cost analysis; Cost-Benefit Analysis; Female; Hematology, Oncology and Palliative Medicine; Humans; Incidence; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - secondary; Male; Mouth Neoplasms - diagnostic imaging; Mouth Neoplasms - pathology; Oncology; Positron-Emission Tomography; Radiography, Thoracic - economics; Retrospective Studies; Surgery; Tomography, X-Ray Computed - economics; Treatment delay; Treatment planning; Triiodobenzoic Acids
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2010.12.012

Abstract The purpose of this study was to establish how often routine CT scan of the chest yields positive findings in patients suffering from oral SCC and how it influences the treatment in terms of extra diagnostic procedures, treatment planning and treatment delay. Costs of this additional diagnostic approach for pulmonary tumors in a selected group were also calculated. A retrospective study was conducted of a group of 196 patients who were newly diagnosed with a squamous cell carcinoma of the oral cavity between January 2004 and July 2006; 142 hospital files were eligible for reviewing. In 20 (13%) patients chest abnormalities were observed on CT scan of the chest and in 6 (4%) patients malignancy was pathologically confirmed. Both pulmonary second primary tumors and pulmonary metastases were independent of stage of oral malignancy. We found that additional diagnostic procedures did not significantly lengthen the time interval between first consult and start of treatment. The cost of the screening for pulmonary malignancies in the group was € 8.214 per observed pulmonary malignancy. We advocate that CT imaging of the chest should be routinely performed in the diagnostic work up of all patients with a newly discovered SCC of the oral cavity, irrespective of the tumor stage of the oral malignancy.