Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin

• Published in: Toxicology (Amsterdam) 2011-12, Vol.290 (2), p.178-186
• Main Authors: Vallet, Coralie M, Marquez, Béatrice, Nhiri, Naïma, Anantharajah, Ahalieyah, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M, Lallemand, Jean-Yves, Jacquet, Eric, Van Bambeke, Françoise
• Format: Article
• Language: English
• Subjects: ABC transporters; Animals; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - pharmacokinetics; Anti-Infective Agents - toxicity; Antibacterial agents; antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; ATP-Binding Cassette Transporters - drug effects; ATP-Binding Cassette Transporters - metabolism; Aza Compounds - administration & dosage; Aza Compounds - pharmacokinetics; Aza Compounds - toxicity; Bcrp; Biological and medical sciences; Cell Line; Chemical Sciences; chronic exposure; Ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Ciprofloxacin - toxicity; Dose-Response Relationship, Drug; drug interactions; drugs; Efflux; Emergency; Fluoroquinolones; Gene Expression Regulation - drug effects; macrophages; Macrophages - drug effects; Macrophages - metabolism; Medical sciences; Mice; Moxifloxacin; Mrp4; Organic chemistry; P-gp; Pharmacology. Drug treatments; Quinolines - administration & dosage; Quinolines - pharmacokinetics; Quinolines - toxicity; toxicity; Toxicology
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2011.09.003

Highlights ► The study examines the expression of ABC transporters in J774 macrophages exposed to moxifloxacin. ► Pleiotropic modifications were observed. ► The expression of Mrp4, the main transporter for ciprofloxacin, was reduced. ► The expression of P-gp, Mrp2, and Bcrp1 was increased. ► These changes result in an increased accumulation of ciprofloxacin but not of moxifloxacin.