Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2012-02, Vol.10 (6), p.1154-1157
Main Authors: Tuncel, Sinem, Fournier-dit-Chabert, Jérémie, Albrieux, Florian, Ahsen, Vefa, Ducki, Sylvie, Dumoulin, Fabienne
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - chemical synthesis
Angiogenesis Inhibitors - chemistry
Chalcone - analogs & derivatives
Chalcone - chemistry
Drug Design
Indoles - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(ii) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob06809e