Triiodothyronine modulates initiation of spermatogenesis in rats depending on treatment timing and blood level of the hormone

Triiodothyronine (T3) stimulates spermatogenic onset but the influence of T3 on spermatogonia development is unknown. The aim of the study was to investigate the role of T3 for both processes simultaneously. Male rats were given daily injections of 100 μg T3/kg body weight or vehicle from birth unti...

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Published in:Molecular and cellular endocrinology 2011-07, Vol.341 (1), p.25-34
Main Authors: Marchlewska, Katarzyna, Kula, Krzysztof, Walczak-Jedrzejowska, Renata, Oszukowska, Elzbieta, Orkisz, Stanisław, Slowikowska-Hilczer, Jolanta
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biochemistry, Molecular Biology
blood serum
Body Weight
Cell Count
Cell Differentiation
Cell Proliferation
Estradiol
Female
Follicle Stimulating Hormone - blood
Gonocyte
Life Sciences
Male
Maturation
Organ Size
Rats
Rats, Wistar
Seminiferous Tubules - cytology
Seminiferous Tubules - drug effects
Sertoli cell
Sertoli Cells - cytology
spermatogenesis
Spermatogenesis - drug effects
Spermatogonia
Spermatozoa - cytology
Testes
Testis - anatomy & histology
Testis - cytology
Testis - drug effects
Testosterone - blood
Thyroid hormone
triiodothyronine
Triiodothyronine - blood
Triiodothyronine - pharmacology
Triiodothyronine - physiology
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Summary:Triiodothyronine (T3) stimulates spermatogenic onset but the influence of T3 on spermatogonia development is unknown. The aim of the study was to investigate the role of T3 for both processes simultaneously. Male rats were given daily injections of 100 μg T3/kg body weight or vehicle from birth until postnatal day (pnd) 5 and euthanized on pnd 6 (short T3-sT3). Other rats, euthanized on pnd 16, were treated either transiently with T3 (tT3) during the initial 5 days or continuously until pnd 15 (cT3). sT3 was found to increase gonocyte differentiation, spermatogonia number, cell degeneration and proliferation. tT3 increased serum T3 level and spermatogonial development to adult values precociously, but cell degeneration or proliferation were not affected. cT3 increased serum T3 together with cell degeneration and proliferation, but cell number was not affected. In conclusion, T3 may modulate spermatogonial development quantitatively depending on treatment timing and blood level of the hormone.
ISSN:0303-7207
1872-8057
0303-7207
DOI:10.1016/j.mce.2011.04.022