Performance of age‐adjusted D‐dimer cut‐off to rule out pulmonary embolism

Background:  Age‐adjusted D‐dimer cut‐off has recently been proposed to increase D‐dimer usefulness in older patients suspected of pulmonary embolism (PE). Objective:  We externally validated this age‐adjusted D‐dimer cut‐off using different D‐dimer assays in a multicenter sample of emergency depart...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2012-07, Vol.10 (7), p.1291-1296
Main Authors: PENALOZA, A., ROY, P.‐M., KLINE, J., VERSCHUREN, F., LE GAL, G., QUENTIN‐GEORGET, S., DELVAU, N., THYS, F.
Format: Article
Language:English
Subjects:
Age Factors
Aged
D‐dimer
Female
Fibrin Fibrinogen Degradation Products - metabolism
Human health and pathology
Humans
Life Sciences
Male
Middle Aged
pulmonary embolism
Pulmonary Embolism - blood
rule‐out
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background:  Age‐adjusted D‐dimer cut‐off has recently been proposed to increase D‐dimer usefulness in older patients suspected of pulmonary embolism (PE). Objective:  We externally validated this age‐adjusted D‐dimer cut‐off using different D‐dimer assays in a multicenter sample of emergency department patients. Methods:  Secondary analysis of three prospectively collected databases (two European, one American) of patients suspected of having PE. D‐dimer performance for ruling out PE was assessed by calculating negative likelihood ratio (nLR) for D‐dimer with age‐adjusted D‐dimer cut‐off (
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2012.04769.x