New Antiplasmodial Bromotyrosine Derivatives from Suberea ianthelliformis Lendenfeld, 1888

Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine‐derived compounds. Two of the new compounds were identified as araplysillin N20‐formamide and its N‐oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolate...

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Bibliographic Details
Published in:Chemistry & biodiversity 2012-08, Vol.9 (8), p.1436-1451
Main Authors: Mani, Luke, Jullian, Valerie, Mourkazel, Beatrice, Valentin, Alexis, Dubois, Joëlle, Cresteil, Thierry, Folcher, Eric, Hooper, John N. A., Erpenbeck, Dirk, Aalbersberg, William, Debitus, Cécile
Format: Article
Language:English
Subjects:
Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Base Sequence
Bromotyrosine derivatives
Chemical Sciences
Humans
Malaria, Falciparum - drug therapy
Molecular Sequence Data
Organic chemistry
Plasmodium falciparum - drug effects
Porifera - chemistry
Sponges
Suberea ianthelliformis
Tyrosine
Tyrosine - analogs & derivatives
Tyrosine - chemistry
Tyrosine - isolation & purification
Tyrosine - pharmacology
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Summary:Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine‐derived compounds. Two of the new compounds were identified as araplysillin N20‐formamide and its N‐oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine‐resistant and ‐sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201100309