Synthesis Of New Polymer Matrices Including Amino Acids

• Published in: Journal of peptide science 2010, Vol.16 (1)
• Main Authors: Danalev, L., Ringeard, J. M., Serfaty, Sylvia, Le Huerou, J. Y., Caplain, E., Griesmar, P.
• Format: Article
• Language: English
• Subjects: Chemical Sciences; Material chemistry
• ISSN: 1075-2617; 1099-1387

Currently the application of biomolecules such as amino acids, carbohydrates and nucleic acids in the diagnostic and treatment (drug delivery) of wide number of diseases turned on the effort of many scientific groups on their encapsulation[ ]. The matrices based on different organic or/and inorganic materials were used. Significant problems arise due to multifunctionality of these molecules. The choice of polymer matrix as well as suitable approach for first amino acid bonding plays a crucial role of biomolecule incorporation process. The sol-gel technology is a modern technique to obtain hybrid polymer matrices. It is based on the hydrolysis of starting materials and further polycondensation process. The strictly control of these processes plays key role for the properties of final materials as well as the protection against precipitates formation. Herein we report for several strategies for amino acid incorporation in organic and/or inorganic polymers. Different type of amino acids (either with different pKa or spatial obstructed group) is linked in order to study the structure of the final material. The rheological properties (elasticity and viscosity) of these matrices are studied by means of an ultrasonic technique developed in our laboratory. The experimental results of the G' and G" moduli for different condition of elaboration is used to access to the microstructure evolution [ ]. Some advantages and defaults due to type of amino acid protection as well as solvent systems used for polymerization process will be discussed. The obtained matrices will be further used for biosensors and bioreactors design.