Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids...

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Bibliographic Details
Published in:Fitoterapia 2012-12, Vol.83 (8), p.1391-1395
Main Authors: Awang, Khalijah, Loong, Xe-Min, Leong, Kok Hoong, Supratman, Unang, Litaudon, Marc, Mukhtar, Mat Ropi, Mohamad, Khalit
Format: Article
Language:English
Subjects:
24(E)-cycloart-24-ene-26-ol-3-one
Aglaia
Aglaia exima
Biological and medical sciences
Chemical Sciences
colon
Cycloartane
Cytotoxicity
General pharmacology
inhibitory concentration 50
leaves
liver
mass spectrometry
Medical sciences
Meliaceae
nuclear magnetic resonance spectroscopy
Organic chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Steroids
triterpenoids
ultraviolet-visible spectroscopy
X-radiation
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Summary:A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5μM). [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2012.10.004