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Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)
A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids...
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| Published in: | Fitoterapia 2012-12, Vol.83 (8), p.1391-1395 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c450t-7d5e03a65a255884cd6ed8eae3c123a782cb933199ffe1c5feeffe0623637723 |
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| cites | cdi_FETCH-LOGICAL-c450t-7d5e03a65a255884cd6ed8eae3c123a782cb933199ffe1c5feeffe0623637723 |
| container_end_page | 1395 |
| container_issue | 8 |
| container_start_page | 1391 |
| container_title | Fitoterapia |
| container_volume | 83 |
| creator | Awang, Khalijah Loong, Xe-Min Leong, Kok Hoong Supratman, Unang Litaudon, Marc Mukhtar, Mat Ropi Mohamad, Khalit |
| description | A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5μM).
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| doi_str_mv | 10.1016/j.fitote.2012.10.004 |
| format | article |
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[Display omitted]</description><subject>24(E)-cycloart-24-ene-26-ol-3-one</subject><subject>Aglaia</subject><subject>Aglaia exima</subject><subject>Biological and medical sciences</subject><subject>Chemical Sciences</subject><subject>colon</subject><subject>Cycloartane</subject><subject>Cytotoxicity</subject><subject>General pharmacology</subject><subject>inhibitory concentration 50</subject><subject>leaves</subject><subject>liver</subject><subject>mass spectrometry</subject><subject>Medical sciences</subject><subject>Meliaceae</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Organic chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Steroids</topic><topic>triterpenoids</topic><topic>ultraviolet-visible spectroscopy</topic><topic>X-radiation</topic><toplevel>online_resources</toplevel><creatorcontrib>Awang, Khalijah</creatorcontrib><creatorcontrib>Loong, Xe-Min</creatorcontrib><creatorcontrib>Leong, Kok Hoong</creatorcontrib><creatorcontrib>Supratman, Unang</creatorcontrib><creatorcontrib>Litaudon, Marc</creatorcontrib><creatorcontrib>Mukhtar, Mat Ropi</creatorcontrib><creatorcontrib>Mohamad, Khalit</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Fitoterapia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awang, Khalijah</au><au>Loong, Xe-Min</au><au>Leong, Kok Hoong</au><au>Supratman, Unang</au><au>Litaudon, Marc</au><au>Mukhtar, Mat Ropi</au><au>Mohamad, Khalit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)</atitle><jtitle>Fitoterapia</jtitle><date>2012-12-01</date><risdate>2012</risdate><volume>83</volume><issue>8</issue><spage>1391</spage><epage>1395</epage><pages>1391-1395</pages><issn>0367-326X</issn><eissn>1873-6971</eissn><abstract>A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5μM).
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| fulltext | fulltext |
| identifier | ISSN: 0367-326X |
| ispartof | Fitoterapia, 2012-12, Vol.83 (8), p.1391-1395 |
| issn | 0367-326X 1873-6971 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00785634v1 |
| source | ScienceDirect Freedom Collection |
| subjects | 24(E)-cycloart-24-ene-26-ol-3-one Aglaia Aglaia exima Biological and medical sciences Chemical Sciences colon Cycloartane Cytotoxicity General pharmacology inhibitory concentration 50 leaves liver mass spectrometry Medical sciences Meliaceae nuclear magnetic resonance spectroscopy Organic chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Steroids triterpenoids ultraviolet-visible spectroscopy X-radiation |
| title | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
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