Synthesis and evaluation of 1-(1 H-indol-3-yl)ethanamine derivatives as new antibacterial agents

A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit t...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2011-05, Vol.19 (10), p.3204-3215
Main Authors: Burchak, Olga N., Pihive, Emmanuelle Le, Maigre, Laure, Guinchard, Xavier, Bouhours, Pascale, Jolivalt, Claude, Schneider, Dominique, Maurin, Max, Giglione, Carmela, Meinnel, Thierry, Paris, Jean-Marc, Denis, Jean-Noël
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
antibacterial properties
antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria
Bacteria - drug effects
Bacterial Infections
Bacterial Infections - drug therapy
Biodiversity
Biological and medical sciences
chemistry
Humans
Indoles
Indoles - chemical synthesis
Indoles - chemistry
Indoles - pharmacology
Indolic derivatives
Life Sciences
Medical sciences
Microbial Sensitivity Tests
minimum inhibitory concentration
pathogens
Pharmacology. Drug treatments
Populations and Evolution
Staphylococcal Infections
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Structure-Activity Relationship
Substituted hydroxylamines
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Summary:A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2011.03.060