Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridines with Aryl Bromides at Low Catalyst Loading

Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1–0.01 mol % catalyst with electron-deficient and some electron-excessive aryl bromides.

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Bibliographic Details
Published in:Journal of organic chemistry 2012-05, Vol.77 (9), p.4473-4478
Main Authors: Fu, Hai Yan, Chen, Lu, Doucet, Henri
Format: Article
Language:English
Subjects:
Catalysis
Catalysts: preparations and properties
Chemical Sciences
Chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Description
Summary:Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1–0.01 mol % catalyst with electron-deficient and some electron-excessive aryl bromides.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo300528b