Biomimetic Membrane System Composed of a Composite Interpenetrating Hydrogel Film and a Lipid Bilayer

A simple way to form an interpenetrating hydrogel (IPH) by combining a layer‐by‐layer polyelectrolyte membrane with agarose is reported. The formed IPH membrane is more robust and easily manipulated compared to a polyelectrolyte membrane with the same number of layers. The IPH has good diffusion cha...

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Bibliographic Details
Published in:Advanced functional materials 2012-10, Vol.22 (20), p.4259-4267
Main Authors: Stidder, Barry, Alcaraz, Jean-Pierre, Liguori, Lavinia, Khalef, Nawel, Bakri, Aziz, Watkins, Erik B., Cinquin, Philippe, Martin, Donald K.
Format: Article
Language:English
Subjects:
agarose
biomimetic membrane
Biotechnology
Computer Science
interpenetrating hydrogel
layer-by-layer
Life Sciences
polyelectrolyte
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Summary:A simple way to form an interpenetrating hydrogel (IPH) by combining a layer‐by‐layer polyelectrolyte membrane with agarose is reported. The formed IPH membrane is more robust and easily manipulated compared to a polyelectrolyte membrane with the same number of layers. The IPH has good diffusion characteristics and retains the advantageous surface charge from the polyectrolyte composition that facilitates the adsorption of a stable lipid bilayer. The stable adsorption of a lipid bilayer on the IPH creates a biomimetic membrane system that is optimized for utilization in a diffusion chamber. An interpenetrating hydrogel (IPH) is produced by combining a layer‐by‐layer polyelectrolyte membrane with agarose. The formed IPH membrane is more robust and easily manipulated and facilitates the adsorption of a stable lipid bilayer. The stable adsorption of a lipid bilayer on the IPH creates a biomimetic membrane system that is optimized for utilization in a diffusion chamber.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201200751