Synthesis, characterization and coordination chemistry of substituted β-amino dicarbonyls

An efficient and facile method for the synthesis of novel structurally diverse β-amino dicarbonyl compounds is described by exploring the aza-Michael addition reaction in an aqueous medium as a key step. Thereby, 2-(aryl-disubstituted-amino-1-yl-methyl)-malonic acid diethyl esters were achieved in a...

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Bibliographic Details
Published in:Journal of Saudi Chemical Society 2012-04, Vol.16 (2), p.161-173
Main Authors: Meskini, Ihssan, Daoudi, Maria, Kerbal, Abdelali, Bennani, Brahim, Sheikh, Javed, Parvez, Ali, Toupet, Loic, Hadda, Taibi Ben
Format: Article
Language:English
Subjects:
Carbonyl compounds
Chemical Sciences
Crystallography
Michael reaction
Organic chemistry
Synthesis
β-Amino dicarbonyls
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Summary:An efficient and facile method for the synthesis of novel structurally diverse β-amino dicarbonyl compounds is described by exploring the aza-Michael addition reaction in an aqueous medium as a key step. Thereby, 2-(aryl-disubstituted-amino-1-yl-methyl)-malonic acid diethyl esters were achieved in a good to excellent yields. These products were easily isolated with enough purity just by using simple recrystallization. The crystals of the compounds (17) and (24) have been obtained and studied by X-ray crystallographic analyses.
ISSN:1319-6103
2212-4640
DOI:10.1016/j.jscs.2010.12.005