The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases

Abstract Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as w...

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Bibliographic Details
Published in:Journal of neuroimmunology 2010-07, Vol.224 (1), p.93-100
Main Authors: Conductier, Grégory, Blondeau, Nicolas, Guyon, Alice, Nahon, Jean-Louis, Rovère, Carole
Format: Article
Language:English
Subjects:
Allergy and Immunology
Alzheimer Disease
Alzheimer Disease - immunology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Animals
Brain
Brain - immunology
Brain - metabolism
Brain - pathology
CCL2
CCR2
Chemokine CCL2
Chemokine CCL2 - biosynthesis
Chemokine CCL2 - genetics
Chemokine CCL2 - physiology
Chemokines
Chemotaxis, Leukocyte
Chemotaxis, Leukocyte - immunology
Humans
Life Sciences
Multiple Sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
Neuroinflammation
Neurology
Neurons and Cognition
Receptors, CCR2
Receptors, CCR2 - biosynthesis
Receptors, CCR2 - genetics
Receptors, CCR2 - physiology
Strok
Stroke
Stroke - immunology
Stroke - metabolism
Stroke - pathology
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Summary:Abstract Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as well as during chronic affections like multiple sclerosis or Alzheimer’s disease, inflammation occurs in order to “clean up” the lesion and to limit its area. Nevertheless, prolonged and sustained inflammation may have cytotoxic effects, aggravating the incidence and the severity of the disease. Among molecules produced during inflammation associated to neuronal death, monocyte chemoattractant proteins (MCPs) seem to be particularly important. This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2010.05.010