Synthesis of Stachybotrin C and All of Its Stereoisomers: Structure Revision

We disclose the first total synthesis of stachybotrin C, a potent neuroprotective natural compound. All of the four stereoisomers have been prepared and fully characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters of the stachybotrin C.

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Bibliographic Details
Published in:Journal of organic chemistry 2013-07, Vol.78 (14), p.7169-7175
Main Authors: Jacolot, Maiwenn, Jean, Mickael, Tumma, Naresh, Bondon, Arnaud, Chandrasekhar, Srivari, van de Weghe, Pierre
Format: Article
Language:English
Subjects:
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Biochemistry, Molecular Biology
Indoles - chemical synthesis
Indoles - chemistry
Life Sciences
Molecular Structure
Stereoisomerism
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Description
Summary:We disclose the first total synthesis of stachybotrin C, a potent neuroprotective natural compound. All of the four stereoisomers have been prepared and fully characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters of the stachybotrin C.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo401116r