Distribution of neurokinin A-like and serotonin immunoreactivities within the vertical lobe complex in Sepia officinalis

Abstract Immunohistochemistry, using antibodies raised against mammalian neurokinin A (NKA) and serotonin (5-HT), was applied in double-staining experiments to map these molecules within the vertical lobe complex (inferior frontal, superior frontal, post-frontal, vertical, subvertical and precommiss...

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Bibliographic Details
Published in:Brain research 2007-02, Vol.1133 (1), p.53-66
Main Authors: Boyer, Christophe, Maubert, Eric, Charnay, Yves, Chichery, Raymond
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Biochemistry. Physiology. Immunology
Biogenic amines
Biological and medical sciences
Brain - anatomy & histology
Brain - metabolism
Cephalopoda
Cognitive science
Cuttlefish
Fundamental and applied biological sciences. Psychology
Immunohistochemistry
Invertebrates
Learning - physiology
Male
Memory neural network
Mollusca
Neurokinin A - metabolism
Neurology
Neurons - metabolism
Neuropeptide
Neuroscience
Physiology. Development
Sepia - anatomy & histology
Sepia - metabolism
Sepia officinalis
Serotonin - metabolism
Tachykinin
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Summary:Abstract Immunohistochemistry, using antibodies raised against mammalian neurokinin A (NKA) and serotonin (5-HT), was applied in double-staining experiments to map these molecules within the vertical lobe complex (inferior frontal, superior frontal, post-frontal, vertical, subvertical and precommissural lobes). NKA-like and 5-HT immunoreactivities were detected in all the lobes of the vertical lobe complex but were never colocalized in cell bodies or fibres. Except for the cell layers of the superior frontal lobe, both types of labelled cell bodies were observed in all the lobes. Both types of immunoreactive fibres were detected in all the neuropils and interestingly revealed clear subdivisions within some lobes, e.g., 5-HT-IR fibres were more abundant in the peripheral part of the vertical lobe whereas NKA-IR ones were widely observed in both the peripheral and central parts. In cephalopods, the vertical lobe complex is involved in learning and memory; thus, our results strongly suggest that one or more NKA-like and 5-HT molecules may function as neurochemical messengers in these cognitive processes.
ISSN:0006-8993
1872-6240
0006-8993
DOI:10.1016/j.brainres.2006.11.042