Lichenic extracts and metabolites as UV filters

• Published in: Journal of photochemistry and photobiology. B, Biology Biology, 2013-03, Vol.120, p.17-28
• Main Authors: Lohézic-Le Dévéhat, Françoise, Legouin, Béatrice, Couteau, Céline, Boustie, Joël, Coiffard, Laurence
• Format: Article
• Language: English
• Subjects: Antioxidants; Antioxidants - isolation & purification; Antioxidants - metabolism; Antioxidants - pharmacology; Antioxidants - toxicity; Ascomycota; Ascomycota - chemistry; Ascomycota - metabolism; ascorbic acid; Benzoates; Benzoates - isolation & purification; Benzoates - metabolism; Benzoates - pharmacology; Benzoates - toxicity; Benzofurans; Benzofurans - isolation & purification; Benzofurans - metabolism; Benzofurans - pharmacology; Benzofurans - toxicity; Biochemistry; Biochemistry, Molecular Biology; Cell Line; cytotoxicity; Fumarates; Fumarates - isolation & purification; Fumarates - metabolism; Fumarates - pharmacology; Fumarates - toxicity; Gyrophoric acid; Humans; irradiation; Lactones; Lactones - isolation & purification; Lactones - metabolism; Lactones - pharmacology; Lactones - toxicity; Lasallia pustulata; Lichen; lichens; Life Sciences; metabolites; photobiology; photochemistry; Photoprotection; Protection Factor-UVA; Salicylates; Salicylates - isolation & purification; Salicylates - metabolism; Salicylates - pharmacology; Salicylates - toxicity; Sun Protection Factor; Sun Protection Factor - methods; superoxide anion; Ultraviolet Rays; Usnea; Usnea - chemistry; Usnea - metabolism; UV filters
• ISSN: 1011-1344; 1873-2682; 1011-1344
• DOI: 10.1016/j.jphotobiol.2013.01.009

[Display omitted] ► Lichen extracts and compounds are evaluated for their photoprotective activities. ► Lasallia pustulata extract and gyrophoric acid are valuable UV filters candidates. ► Salazinic acid presents characteristics of a UVA booster. Three lichen extracts and ten lichenic compounds have been screened for their photoprotective activities. The determination of their Sun Protection Factor (SPF) and Protection Factor-UVA (PF-UVA) values was done in vitro. Among them, a Lasallia pustulata extract and gyrophoric acid exhibited SPF values over 5, which is better than Homosalate (SPF≈4). Their photoprotective properties are only slightly modified after a 2-hours period of irradiation. Salazinic acid and L. pustulata presented characteristics of a UVA booster like the butyl-methoxydibenzoylmethane (Avobenzone) (PF-UVA≈2 vs. 2.8 for Avobenzone). Salazinic acid was a better anion superoxide scavenger than ascorbic acid and none of them exhibited a photosensitizing cytotoxicity by exposing them on HaCaT cells to UVA radiations (photo-irritancy factor PIF