First Brønsted acid catalyzed asymmetric aldol reaction: a complementary approach to enamine catalysis

A syn-enantioselective aldol reaction has been developed using Brønsted acid catalysis based on H(8)-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various beta-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.

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Bibliographic Details
Published in:Organic letters 2010-08, Vol.12 (16), p.3582-5
Main Authors: Pousse, Guillaume, Le Cavelier, Fabien, Humphreys, Luke, Rouden, Jacques, Blanchet, Jérôme
Format: Article
Language:English
Subjects:
Chemical Sciences
Organic chemistry
Online Access:Get full text
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Description
Summary:A syn-enantioselective aldol reaction has been developed using Brønsted acid catalysis based on H(8)-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various beta-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101176j