Severe bronchiolitis in infants born very preterm and neurodevelopmental outcome at 2 years

Preterm infants are at greater risk of bronchopulmonary dysplasia, which is associated with neurodevelopmental impairment. These infants are also more likely to develop severe bronchiolitis, which can contribute to neurodevelopmental impairment. The aim of this study was to determine whether severe...

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Bibliographic Details
Published in:European journal of pediatrics 2013-05, Vol.172 (5), p.639-644
Main Authors: Gouin, Marion, Nguyen, Sylvie, Savagner, Christophe, Troussier, Francoise, Gascouin, Géraldine, Rozé, Jean-Christophe, Flamant, Cyril
Format: Article
Language:English
Subjects:
Age
Bronchiolitis - epidemiology
Bronchopulmonary Dysplasia - epidemiology
Developmental Disabilities - epidemiology
Female
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature
Male
Medicine
Medicine & Public Health
Nervous System Diseases - epidemiology
Original Article
Pediatrics
Prognosis
Risk Factors
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Summary:Preterm infants are at greater risk of bronchopulmonary dysplasia, which is associated with neurodevelopmental impairment. These infants are also more likely to develop severe bronchiolitis, which can contribute to neurodevelopmental impairment. The aim of this study was to determine whether severe bronchiolitis in very preterm infants (born before 33 weeks of gestation) was associated with an increased risk of neurodevelopmental impairment at 2 years of age. We analyzed a population-based cohort of infants (the Loire Infant Follow-up Team cohort) born between 1 January 2003 and 31 December 2009. Severe bronchiolitis was defined as hospitalization due to bronchiolitis during the first year of life. Neurodevelopmental outcome was assessed at 2 years of corrected age. A total of 2,405 infants were included in this analysis and categorized based on neonatal respiratory status: 1,308 (54.4 %) received no respiratory assistance, 864(35.9 %) received oxygen for
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-013-1940-8