ASYMPTOTIC BEHAVIOR AND NUMERICAL SIMULATIONS FOR AN INFECTION LOAD-STRUCTURED EPIDEMIOLOGICAL MODEL: APPLICATION TO THE TRANSMISSION OF PRION PATHOLOGIES

This article studies an infection load-structured SI model with exponential growth of the infection, that incorporates a potential external source of contamination. We perform the analysis of the time asymptotic behavior of the solution by exhibiting epidemiological thresholds, such as the basic rep...

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Bibliographic Details
Published in:SIAM journal on applied mathematics 2014-01, Vol.74 (5), p.1571-1597
Main Authors: PERASSO, ANTOINE, RAZAFISON, ULRICH
Format: Article
Language:English
Subjects:
Analysis of PDEs
Disease models
Disease transmission
Epidemiology
Infections
Mathematical models
Mathematical theorems
Mathematics
Pathology
Population dynamics
Prion diseases
Prions
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Summary:This article studies an infection load-structured SI model with exponential growth of the infection, that incorporates a potential external source of contamination. We perform the analysis of the time asymptotic behavior of the solution by exhibiting epidemiological thresholds, such as the basic reproduction number, that ensure extinction or persistence of the disease in the contagion process. Moreover, a numerical scheme adapted to the model is developed and analyzed. This scheme is then used to illustrate the model with numerical simulations, applying this last to the transmission of prion pathologies.
ISSN:0036-1399
1095-712X
DOI:10.1137/130946058