Honey-induced macrophage stimulation: AP-1 and NF-κB activation and cytokine production are unrelated to LPS content of honey

Honey is well known for its wound healing properties although the cellular and molecular mechanisms underlying honey-stimulated healing process are still poorly understood. The present study was intended to characterize the stimulation of Raw 264.7 murine macrophages in response to thyme honey. Hone...

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Bibliographic Details
Published in:International immunopharmacology 2013-11, Vol.17 (3), p.874-879
Main Authors: Raynaud, A., Ghezali, L., Gloaguen, V., Liagre, B., Quero, F., Petit, J.M.
Format: Article
Language:English
Subjects:
Animals
AP-1
Biochemistry, Molecular Biology
Cell Line
Chemical Sciences
COX-2
Cyclooxygenase 2 - metabolism
Dinoprostone - metabolism
Honey
Interleukin-6 - metabolism
Life Sciences
Lipopolysaccharides
Macrophages - metabolism
Mice
NF-kappa B - metabolism
NF-κB activation
Organic chemistry
Thyme honey
Thymus
Thymus Plant
TNF-α cytokine
Transcription Factor AP-1 - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:Honey is well known for its wound healing properties although the cellular and molecular mechanisms underlying honey-stimulated healing process are still poorly understood. The present study was intended to characterize the stimulation of Raw 264.7 murine macrophages in response to thyme honey. Honey induces significant increase in PGE2 production, and overexpression of both COX-2 and TNF-α (p
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2013.09.014