A Practical Variation on the Paal-Knorr Pyrrole Synthesis

Abstract The radical addition of α-xanthyl ketones to vinyl pivalate gives adducts that are synthetic equivalents of 1,4-ketoaldehydes; treatment with ammonia or primary amines leads to the corresponding pyrroles in high yield.

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Bibliographic Details
Published in:Synlett 2003-01, Vol.2003 (1), p.75-78
Main Authors: Quiclet-Sire, Béatrice, Quintero, Leticia, Sanchez-Jimenez, Graciela, Zard, Samir Z.
Format: Article
Language:English
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Description
Summary:Abstract The radical addition of α-xanthyl ketones to vinyl pivalate gives adducts that are synthetic equivalents of 1,4-ketoaldehydes; treatment with ammonia or primary amines leads to the corresponding pyrroles in high yield.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-36223