Short cuts toward forskolin synthesis: a pentacyclic approach

A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in t...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2000-01 (18), p.1737-1738
Main Authors: Leclaire, Massoumé, Levet, Raymond, Ferreira, Franck, Ducrot, Paul-Henri, Lallemand Louis Ricard, Jean-Yves
Format: Article
Language:English
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Summary:A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in the formation of the tricyclic core of forskolin.
ISSN:1359-7345
1364-548X
DOI:10.1039/b004515m