Timing of the Intestinal Barrier Closure in Puppies

Contents As puppies are born with very low immunoglobulin concentrations, they rely on passive immune transfer from ingested colostrum to acquire a protective immunity during the first few weeks of life. The purpose of this study was to describe the timing of gut closure in canine neonates. Twenty‐t...

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Bibliographic Details
Published in:Reproduction in domestic animals 2012-12, Vol.47 (s6), p.190-193
Main Authors: Chastant-Maillard, S, Freyburger, L, Marcheteau, E, Thoumire, S, Ravier, JF, Reynaud, K
Format: Article
Language:English
Subjects:
Animal biology
Animal reproduction
Animals
Animals, Newborn
Colostrum
Dogs
Dogs - growth & development
Immunoglobulin A - metabolism
Immunoglobulin G - metabolism
Immunoglobulin M - metabolism
Immunology
Intestinal Absorption - physiology
Intestines - growth & development
Intestines - physiology
Life Sciences
Time Factors
Veterinary medicine and animal Health
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Summary:Contents As puppies are born with very low immunoglobulin concentrations, they rely on passive immune transfer from ingested colostrum to acquire a protective immunity during the first few weeks of life. The purpose of this study was to describe the timing of gut closure in canine neonates. Twenty‐two Beagle puppies received 3 ml of standardized canine colostrum at 0, 4, 8, 12, 16 or 24 h after birth using a feeding tube. Blood immunoglobulins G (IgG, M and A) were assayed 0, 4 and 48 h after colostrum ingestion. IgG absorption rate was significantly affected by the time of colostrum administration, and the IgG concentrations in puppies serum 48 h after administration were significantly higher when colostrum was ingested at 0–4 h of age than at 8–12 h or 16–24 h (1.68 ± 0.4, 0.79 ± 0.07 and 0.35 ± 0.08 g/l, respectively; p 
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.12008