Implications of the human microbiome in inflammatory bowel diseases

Abstract The study of the human microbiome or community of microorganisms and collection of genomes found in the human body is one of the fastest growing research areas because many diseases are reported to be associated with microbiome imbalance or dysbiosis. With the improvement in novel sequencin...

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Bibliographic Details
Published in:FEMS microbiology letters 2013-05, Vol.342 (1), p.10-17
Main Authors: Bakhtiar, Syeda M., LeBlanc, Jean Guy, Salvucci, Emiliano, Ali, Amjad, Martin, Rebeca, Langella, Philippe, Chatel, Jean-Marc, Miyoshi, Anderson, Bermúdez-Humarán, Luis G., Azevedo, Vasco
Format: Article
Language:English
Subjects:
Agricultural sciences
Biological and medical sciences
Biota
Commensal
Fundamental and applied biological sciences. Psychology
High-Throughput Nucleotide Sequencing
Human holobiont
Humans
Inflammatory Bowel Diseases - microbiology
Life Sciences
Metagenome
Microbial activity
Microbiology
Microbiome
Microbiota
Microorganisms
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Summary:Abstract The study of the human microbiome or community of microorganisms and collection of genomes found in the human body is one of the fastest growing research areas because many diseases are reported to be associated with microbiome imbalance or dysbiosis. With the improvement in novel sequencing techniques, researchers are now generating millions of sequences of different sites from the human body and evaluating specific differences in microbial communities. The importance of microbiome constituency is so relevant that several consortia like the Human Microbiome project (HMP) and Metagenomics of the Human Intestinal Tract (MetaHIT) project are focusing mainly on the human microbiome. The aim of this review is to highlight points of research in this field, mainly focusing on particular factors that modulate the microbiome and important insights into its potential impact on our health and well-being.
ISSN:0378-1097
1574-6968
DOI:10.1111/1574-6968.12111