FANCM Limits Meiotic Crossovers

The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is requ...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2012-06, Vol.336 (6088), p.1588-1590
Main Authors: Crismani, Wayne, Girard, Chloé, Froger, Nicole, Pradillo, Mónica, Santos, Juan Luis, Chelysheva, Liudmila, Copenhaver, Gregory P., Horlow, Christine, Mercier, Raphaël
Format: Article
Language:English
Subjects:
Agricultural sciences
Anaphase
Arabidopsis - genetics
Arabidopsis - growth & development
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Biological and medical sciences
Cation Transport Proteins - genetics
Cation Transport Proteins - metabolism
Cell cycle, cell proliferation
Cell division
Cell physiology
Chiasmata
Chromosome Segregation
Chromosomes
Chromosomes, Plant - physiology
Chromosomes, Plant - ultrastructure
Crossing Over, Genetic
Crossovers
Division
DNA Helicases - genetics
DNA Helicases - metabolism
Endonucleases - genetics
Endonucleases - metabolism
Fundamental and applied biological sciences. Psychology
Genetic Complementation Test
Genetic mutation
Genetic recombination
Genomes
Homologous Recombination
Homology
Human
In Situ Hybridization, Fluorescence
Life Sciences
Meiosis
Metaphase
Molecular and cellular biology
Mutation
Pathways
Plant growth
Proteins
Ratios
Schizosaccharomyces pombe
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Summary:The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is required for genome stability in humans and yeasts, as a major factor limiting meiotic CO formation. The fancm mutant has a threefold-increased CO frequency as compared to the wild type. These extra COs arise not from the pathway that accounts for most of the COs in wild type, but from an alternate, normally minor pathway. Thus, FANCM is a key factor imposing an upper limit on the number of meiotic COs, and its manipulation holds much promise for plant breeding.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1220381