Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach

• Published in: The Journal of nutritional biochemistry 2012-02, Vol.23 (2), p.133-139
• Main Authors: He, Qinghua, Ren, Pingping, Kong, Xiangfeng, Wu, Yongning, Wu, Guoyao, Li, Peng, Hao, Fuhua, Tang, Huiru, Blachier, François, Yin, Yulong
• Format: Article
• Language: English
• Subjects: Agricultural sciences; Analysis; Animal subjects; Animals; Biological and medical sciences; Blood; Blood Glucose - analysis; Body Composition; Choline - blood; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glucagon - blood; Insulin - blood; Lean pigs; Life Sciences; Lipid Metabolism; Lipids; Lipoproteins, HDL - blood; Lipoproteins, VLDL - blood; Magnetic Resonance Spectroscopy - methods; Metabolism; Metabolomics; Metabonomics; Methylamines - blood; Multivariate Analysis; Muscles (size); Obese pigs; Obesity; Obesity - blood; Obesity - metabolism; Proteins; Serum; Strains; Swine - blood; Swine - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2010.11.007

Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean (Duroc×Landrace×Large Yorkshire strain) growing pigs were used as models to identify potential differences in the serum metabonome between the two strains of pigs after consuming the same diet for 46 days. At the end of the study, pigs were euthanized for analysis of the serum metabonome and determination of body composition. Obese pigs had higher fat mass (42.3±8.8% vs. 21.9±4.5%) and lower muscle mass (35.4±4.5% vs. 58.9±2.5%) than lean pigs ( P