Organocatalytic Asymmetric Hetero-Diels-Alder Reaction of Oxindoles under High Pressure

Abstract A general and efficient protocol for the high-pressure-promoted asymmetric hetero-Diels-Alder reactions of oxindoles has been developed. These reactions can be realized by using chiral thiourea-derived organocatalysts, and the desired adducts are obtained in good to high yields with good to...

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Bibliographic Details
Published in:Synlett 2011-09, Vol.22 (14), p.2080-2084
Main Authors: Mori, Kaori, Yamauchi, Tomoyuki, Maddaluno, Jacques, Nakano, Keiji, Ichikawa, Yoshiyasu, Kotsuki, Hiyoshizo
Format: Article
Language:English
Subjects:
Chemical Sciences
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
letter
Organic chemistry
Preparations and properties
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Summary:Abstract A general and efficient protocol for the high-pressure-promoted asymmetric hetero-Diels-Alder reactions of oxindoles has been developed. These reactions can be realized by using chiral thiourea-derived organocatalysts, and the desired adducts are obtained in good to high yields with good to moderate enantioselectivity.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0030-1260986