β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group

Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the...

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Bibliographic Details
Published in:Amino acids 2014-12, Vol.46 (12), p.2753-2757
Main Authors: Stanovych, Andrii, Guillot, Régis, Kouklovsky, Cyrille, Miclet, Emeric, Alezra, Valérie
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids, Diamino - chemistry
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Chemical Sciences
Hydrogen Bonding
Hydrogen bonds
Life Sciences
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular dynamics
Molecular Structure
Neurobiology
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Organic chemistry
Original Article
Peptides
Peptides - chemical synthesis
Peptides - chemistry
Proteomics
Synthesis
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Summary:Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the β-nitrogen.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-014-1831-y