Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

Abstract Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders 2013-10, Vol.2 (4), p.263-269
Main Authors: Inglese, M, Oesingmann, N, Zaaraoui, W, Ranjeva, J.P, Fleysher, L
Format: Article
Language:English
Subjects:
Engineering Sciences
Multiple Sclerosis
Multiple-quantum filtering
Neurology
Sodium imaging
Ultra-high magnetic field
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Summary:Abstract Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.
ISSN:2211-0348
2211-0356
2211-0356
2211-0348
DOI:10.1016/j.msard.2013.03.009