Recent advances in theranostic nanocarriers of doxorubicin based on iron oxide and gold nanoparticles

Hybrid (organic/inorganic) nanoparticles emerged as a simple solution to build “theranostic” systems. Due to their physical properties, superparamagnetic iron oxide nanoparticles (SPIONs) and plasmonic gold nanoparticles (Au-NPs) are extensively studied as a part of diagnostic and therapeutic strate...

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Bibliographic Details
Published in:Journal of controlled release 2013-07, Vol.169 (1-2), p.48-61
Main Authors: Gautier, J., Allard-Vannier, E., Munnier, E., Soucé, M., Chourpa, I.
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Antibiotics, Antineoplastic - administration & dosage
Bioengineering
Biomaterials
Chemical Sciences
Doxorubicin
Doxorubicin - administration & dosage
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems - methods
Ferric Compounds - chemistry
Gold - chemistry
Gold nanocarriers
Humans
hybrids
image analysis
Iron oxide nanocarriers
iron oxides
Life Sciences
Medication
nanocarriers
nanogold
nanoparticles
Nanoparticles - chemistry
Neoplasms - drug therapy
Pharmaceutical sciences
physical properties
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Summary:Hybrid (organic/inorganic) nanoparticles emerged as a simple solution to build “theranostic” systems. Due to their physical properties, superparamagnetic iron oxide nanoparticles (SPIONs) and plasmonic gold nanoparticles (Au-NPs) are extensively studied as a part of diagnostic and therapeutic strategies in cancer treatments. They can be used as agents for in vitro or in vivo imaging, for magnetic drug targeting and/or thermal therapy. Their functionalization with organic shells enhances their potential performance in tumor targeting and drug delivery. The advances in such hybrid nanocarriers are well illustrated with the example of the anticancer drug doxorubicin (DOX). The aim of this review is to give a multidisciplinary overview of such smart nanosystems loaded with DOX, based on examples taken from recent publications. From a physico-chemical point of view, we discuss the choices for the strategies for loading DOX and the consequences on drug release. From a biological point of view, we analyze the in vitro and in vivo assays concerning tumor imaging, targeted drug delivery and anticancer efficiency. Future opportunities and challenges are also addressed. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2013.03.018