Characterization of major elements of insulin signaling cascade in chicken adipose tissue: Apparent insulin refractoriness

• Published in: General and comparative endocrinology 2012-03, Vol.176 (1), p.86-93
• Main Authors: Dupont, Joëlle, Métayer-Coustard, Sonia, Ji, Bo, Ramé, Christelle, Gespach, Christian, Voy, Brynn, Simon, Jean
• Format: Article
• Language: English
• Subjects: Abdominal fat; Abdominal Fat - metabolism; adipose tissue; Animals; Avian; chickens; Chickens - metabolism; Cyclic AMP Response Element-Binding Protein - metabolism; Endocrinology & Metabolism; Endocrinology and metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; fasting; Fasting - physiology; glucagon; Human health and pathology; insulin; Insulin - metabolism; Insulin receptor; Insulin Receptor Substrate Proteins - metabolism; insulin resistance; Insulin Resistance - physiology; Life Sciences; Liver - metabolism; Male; MAP Kinase Signaling System - physiology; Metabolism; mitogen-activated protein kinase; Muscle, Skeletal - metabolism; neutralization; nutritional status; p38 Mitogen-Activated Protein Kinases - metabolism; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - metabolism; phosphorylation; Phosphorylation - physiology; Proto-Oncogene Proteins c-akt - metabolism; Rats; Receptor, Insulin - metabolism; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Shc Signaling Adaptor Proteins - metabolism; Signal transduction; transcription factors; tyrosine
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2011.12.030

Highlights ► We identified insulin signaling components in chicken adipose tissue. ► The activation of these components is insensitive to fasting. ► Insulin immuno-neutralization does not affect insulin signaling in chicken fat.