Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers

Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T1 measurements were performed to determ...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2013, Vol.101A, p.613-621
Main Authors: Balieu, S., Cadiou, Cyril, Martinez, A., Nuzillard, J.-M., Oudart, J.-B., Maquart, F.-X., Chuburu, F., Bouquillon, S.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemical Sciences
Organic chemistry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T1 measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34359