Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers

Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T1 measurements were performed to determ...

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Published in:Journal of biomedical materials research. Part A 2013, Vol.101A, p.613-621
Main Authors: Balieu, S., Cadiou, Cyril, Martinez, A., Nuzillard, J.-M., Oudart, J.-B., Maquart, F.-X., Chuburu, F., Bouquillon, S.
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Language:English
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Analytical chemistry
Chemical Sciences
Organic chemistry
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container_title Journal of biomedical materials research. Part A
container_volume 101A
creator Balieu, S.
Cadiou, Cyril
Martinez, A.
Nuzillard, J.-M.
Oudart, J.-B.
Maquart, F.-X.
Chuburu, F.
Bouquillon, S.
description Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T1 measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity
doi_str_mv 10.1002/jbm.a.34359
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subjects Analytical chemistry
Chemical Sciences
Organic chemistry
title Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers
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