Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging

Herein, we show that a far-red arylidene-squaraine dye is stable against nucleophiles, in contrast to arene-squaraines. Owing to the fluorescence enhancement in apolar media together with high brightness and photostability, this dye was successfully applied to detect the oxytocin G protein-coupled r...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-02, Vol.51 (14), p.296-2963
Main Authors: Karpenko, J, Klymchenko, A. S, Gioria, S, Kreder, R, Shulov, I, Villa, P, Mély, Y, Hibert, M, Bonnet, D
Format: Article
Language:English
Subjects:
Animals
Brightness
Cattle
Cells (biology)
Color
Cyclobutanes - chemistry
Dyes
Fluorescence
Fluorescent Dyes - chemistry
HEK293 Cells
Humans
Labels
Life Sciences
Molecular Imaging
Monitors
Nucleophiles
Phenols - chemistry
Protein Transport
Receptors
Receptors, Oxytocin - chemistry
Receptors, Oxytocin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herein, we show that a far-red arylidene-squaraine dye is stable against nucleophiles, in contrast to arene-squaraines. Owing to the fluorescence enhancement in apolar media together with high brightness and photostability, this dye was successfully applied to detect the oxytocin G protein-coupled receptor and monitor its internalization in living cells. A stable, highly fluorescent and environment-sensitive far-red probe derived from squaraine visualizes the oxytocin receptor in living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc09113b