Dicorynamine and harmalan-N-oxide, two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood

•Four indole alkaloids were isolated from the heartwood of Dicorynia guianensis.•Two new compounds were identified: spiroindolone (1) nitrone and (3) derivatives.•Compounds 1 and 3 were isolated for the first time as natural products. The chemical investigations of Dicorynia guianensis heartwood led...

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Bibliographic Details
Published in:Phytochemistry letters 2015-06, Vol.12, p.158-163
Main Authors: Anouhe, Jean-Baptiste Say, Adima, Augustin Amissa, Niamké, Florence Bobelé, Stien, Didier, Amian, Brise Kassi, Blandinières, Pierre-Alain, Virieux, David, Pirat, Jean-Luc, Kati-Coulibaly, Seraphin, Amusant, Nadine
Format: Article
Language:English
Subjects:
ABTS antioxidant
Biogenesis
Chemical Sciences
Dicorynia guianensis
Nitrone
Spiroindolone
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Summary:•Four indole alkaloids were isolated from the heartwood of Dicorynia guianensis.•Two new compounds were identified: spiroindolone (1) nitrone and (3) derivatives.•Compounds 1 and 3 were isolated for the first time as natural products. The chemical investigations of Dicorynia guianensis heartwood led to the isolation of four new indole alkaloids for the first time in this plant. Compound (1) identified as spiroindolone 2′,3′,4′,9′-tetrahydrospiro [indoline-3,1′pyrido[3,4-b]-indol]-2-one, and compound (3) described as nitrone 1-methyl-4,9-dihydro-3H-pyrido [3,4-b] indole 2-oxide and were isolated for the first time as natural products. ABTS antioxidant activity guided their isolation.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2015.03.012