Oxidation Catalysis by Rationally Designed Artificial Metalloenzymes

The principle of enzyme mimics has been raised to its pinnacle by the design of hybrids made from inorganic complexes embedded into biomolecules. The present review focuses on the design of artificial metalloenzymes for oxidation reactions by oxygen transfer reactions, with a special focus on protei...

Full description

Saved in:
Bibliographic Details
Published in:Israel journal of chemistry 2015-01, Vol.55 (1), p.61-75
Main Authors: Marchi-Delapierre, Caroline, Rondot, Laurianne, Cavazza, Christine, Ménage, Stéphane
Format: Article
Language:English
Subjects:
artificial enzyme
biocatalysis
Biochemistry
Biochemistry, Molecular Biology
Biomolecules
Catalysis
Chemical Sciences
Coordination compounds
Cristallography
Enzymes
iron
Life Sciences
Oxidation
protein crystallography
Proteins
Sustainability
Synthesis (chemistry)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The principle of enzyme mimics has been raised to its pinnacle by the design of hybrids made from inorganic complexes embedded into biomolecules. The present review focuses on the design of artificial metalloenzymes for oxidation reactions by oxygen transfer reactions, with a special focus on proteins anchoring inorganic complexes or metal ions via supramolecular interactions. Such reactions are of great interest for the organic synthesis of building blocks. In the first part, following an overview of the different design of artificial enzymes, the review presents contributions to the rational design of efficient hybrid biocatalysts via supramolecular host/guest approaches, based on the nature of the inorganic complex and the nature of the protein, with special attention to the substrate binding. In the second part, the original purpose of artificial metalloenzymes has been twisted to enable the observation of transient intermediates, to decipher metal‐based oxidation mechanisms. The host protein crystals have been used as crystalline molecular‐scale vessels, within which inorganic catalytic reactions have been followed, thanks to X‐ray crystallography. These hybrids should be an alternative to enzymes for sustainable chemistry.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.201400110